Endocrine Abstracts

Introduction: Breast cancer is, by far, the most frequent cancer among women. Local and systemic factors have been shown to drive growth in breast cancer cells. There is increasing evidence that hormone ghrelin, known for the growth hormone releasing effect and food intake modulator, may also influence cancer growth. Ghrelin has been shown to be produced by some tumor cells, including breast cancer cells.Objective: To analyze ghrelin expression in correl...

Introduction: Calcific Uremic Arteriolopathy (CUA) is a rare but severe complication of end-stage kidney disease with one year survival rates between 45-55%. Extensive skin ulcers and concomitant painful purpura are the clinical features and diagnosis criteria as defined by Hayashi. Parathyroidectomy treatment for hyperparatiroidism is reserved for patients with inadequate response to calcimimetics, persistent elevated PTH>800 pg/ml or calciphylaxis and it has been shown t...

Introduction: White adipose tissue celularity is a highly versatile and precocious marker for metabolic status. Fat morphology can be estimated by comparing body fat mass with average fat cell size. Recent studies have shown that adipo-cyte hypertrophy is negatively correlated with dyslipidemia and insulin resistance, independent of body composition.Methods: The study group includes 18 obese patients, with a mean age of 38.76±8.89 years and a mean B...

Introduction: Sleeve gastrectomy is a highly effective bariatric technique for morbidly obese patients thus nutritional deficiencies resulting need routine screening for proper evaluation.Aim: Little is still known about the nutritional side-effects for this restrictive bariatric procedure and our study aims to evaluate the impact of sleeve gastrectomy on micronutrients status.Methods: Our prospective study included 48 morbidly obe...

Introduction: Short stature is the most common physical abnormality in Turner syndrome (TS), with adult stature averaging 20 cm shorter compared to the general population.Aim: To study the efficiency of early initiation for GH therapy on final stature for patients with Turner syndrome and to prove it’s important role in obtaining optimal growth rates.Methods: We studied a lot of 24 patients with TS diagnosed and followed up in...

Introduction: The adipocyte expansion is a critical process with implications in the pathogenesis of metabolic syndrome and insulin resistance associated to obesity. Impaired adipogenesis leads to dysfunctional, hypertrophic adipocytes, chronic low grade inflammation and insulin resistance.Methods: Our study included 18 obese patients (13 females and 5 males) mean age 38.76±8.89 years and mean body mass index 46.06±6.48 kg/m2, referred for Lapa...

Introduction: ACTH resistance syndromes are rare, autosomal and genetically heterogeneous diseases that include familial glucocorticoid deficiency and triple A syndrome. These are characterised by early onset of primary adrenocortical insufficiency associated with hypoglycaemia, convulsions and skin pigmentation.Case report: We present the case of primary adrenal failure in a boy diagnosed at the age of four, during a decompensation episode with hypoglyc...

We present the case of 13 years old boy referred to our service in June 2013 for bilateral gynecomastia (appeared for ~1 year). The boy’s father presented delayed puberty (at 18-year-old). No other pathological hereditary conditions were reported.Clinical examination revealed: gynoid status with height =167 cm (−1.4 DS), weight=63.5 kg, important bilateral gynecomastia with hypo pigmented areola and painful palpation. Sexual development was PI...